5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride → HCID 86610357, compound

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Reaction Steps

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with (1-tert-butyloxycarbonylpiperidin-4-yl)methylamide as described in Step 5, Example 24 to give the title compound as a solid (54% yield). LC/MS: RT 3.09 min; m/e 496 (M+H); 1H NMR (CDCl3, δ, ppm): 12.19 (1H, br s), 7.56 (1H, d), 7.29 (1H, s), 6.94 (1H, d); 5.15 (1H, t); 4.16 (2H, br t), 3.00 (2H, t), 2.71 (2H, br m), 2.58 (2H, q), 2.45 (3H, s), 1.66 (2H, br m), 1.45 (9H, s), 1.24 (3H, t).

Provenance & Evidence