1-Pyrrolidineethanamine → HCID 71082907, compound

HRID 1921410Notes

Reaction equation

[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[O:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[N:20]1([CH2:25][CH2:26][NH2:27])[CH2:24][CH2:23][CH2:22][CH2:21]1>>[ClH:19].[N:20]1([CH2:25][CH2:26][NH:27][S:16]([C:14]2[O:15][C:11]([C:5]3[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=3[CH3:10])=[CH:12][CH:13]=2)(=[O:18])=[O:17])[CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

Reactant 2

HCID 13441-Pyrrolidineethanamine

HCID 86610360HCID 86610360, compound

Product 1

HCID 71082907HCID 71082907, compoundYield 97%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-sulfonyl chloride is reacted with (2-pyrolidin-1-yl)ethylamine as described in Steps 5 and 6, Example 24 to give the title compound as a solid (97% yield). LC/MS: RT 1.95 min; m/e 380 (M+H); 1H NMR (δ, ppm): 11.86 (1H, s), 8.44 (1H, br t), 7.53 (1H, s), 7.24 (1H, d); 6.74 (1H, d), 3.0-3.89 (8H), 2.39 (5H), 1.85 (4H), 1.09 (3H, t).

Sources & evidence

ORD record: ord-29982b6f21504daf8514ec18f7f56ad8
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173682B2

Reaction notes

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