3,5-Difluorobenzylamine → HCID 58808727, compound

HRID 1921413Notes

Reaction equation

HRID 1921413 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[O:15][C:14]([S:16](Cl)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[F:20][C:21]1[CH:22]=[C:23]([CH:26]=[C:27]([F:29])[CH:28]=1)[CH2:24][NH2:25]>>[F:20][C:21]1[CH:22]=[C:23]([CH:26]=[C:27]([F:29])[CH:28]=1)[CH2:24][NH:25][S:16]([C:14]1[O:15][C:11]([C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=2[CH3:10])=[CH:12][CH:13]=1)(=[O:18])=[O:17]

Participants

3

Reactant 2

HCID 1452113,5-DifluorobenzylamineHCID 86610360HCID 86610360, compound

Product 1

HCID 58808727HCID 58808727, compoundYield 10%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-sulfonyl chloride is reacted with 3,5-difluoro-benzylamine as described in Steps 5 and 6, Example 24 to give the title compound as a solid (10% yield). MS: m/e 409 (M+H).

Sources & evidence

ORD record
ord-a486a953c1bc4269910937f43a030a7c
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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