1,4'-Bipiperidine → HCID 67492406, compound
Reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[N:20]1([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[ClH:19].[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([N:29]3[CH2:30][CH2:31][CH:26]([N:20]4[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]4)[CH2:27][CH2:28]3)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2]Participants
3
Procedure
5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 4-(piperidin-1-yl)piperidine as described in Steps 5 and 6, Example 24 to give the title compound as a white solid (93% yield). LC/MS: RT 2.17 min; m/e 450; 1H NMR (δ, ppm): 11.89 (1H, br), 10.44 (1H, br), 7.64 (1H, d), 7.37 (1H, s), 7.29 (1H, d), 3.78 (2H, d), 3.50 (2H, d), 2.78-2.98 (2H, m), 2.35-2.58 (2H, q), 2.34 (3H, s), 2.20 (2H, d), 1.60-1.96 (8H, m), 1.20-1.50 (2H, m), 1.10 (3H, t).
Sources & evidence
- ORD record
- ord-717196ff09f6474783cd1f0934831acd
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08173682B2
Reaction notes
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