HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Aminopropyl)-2-pyrrolidinone → 5-[5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl]thiophene-2-sulfonic acid [3-(2-oxopyrrolidin-1-yl)propyl]amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Aminopropyl)-2-pyrrolidinone | HCID 82111 | — |
| Reactant | 5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride | HCID 86610352 | — |
| Product | 5-[5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl]thiophene-2-sulfonic acid [3-(2-oxopyrrolidin-1-yl)propyl]amide | HCID 11589903 | 69% |
Reaction Steps
5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 1-(3-aminopropyl)pyrrolidin-2-one as described in Step 5, Example 24 to give the title compound as a white solid (69% yield). LC/MS: RT 2.42 min; m/e 424.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173682B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-9387f72c7fa94458b3ececea19c79216 |
| Source note | uspto-grants-2012_05 |