N-(2-Aminoethyl)piperidine → HCID 11546782, compound

Participants

Reaction Steps

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 2-(piperidin-1-yl)ethylamine as described in Steps 5 and 6, Example 24 to give the title compound as a white solid (60% yield). LC/MS: RT 2.07 min; m/e 410; 1H NMR (δ, ppm): 10.68 (1H, br), 8.39 (1H, s), 7.64 (1H, s), 7.35 (1H, s), 7.20 (1H, s), 3.25-3.50 (4H, m), 2.80-3.00 (2H, m), 2.10-2.60 (7H, m), 1.60-2.00 (4H, m), 1.20-1.40 (2H, m), 1.10 (3H, t).

Provenance & Evidence