1-[2-(2-Hydroxyethoxy)ethyl]piperazine → HCID 67492314, compound

Participants

Reaction Steps

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride (70 mg, 0.220 mmol) is reacted with 2-(2-piperazin-1-yl-ethoxy)-ethanol (41.7 μL, 0.242 mmol) as described in Steps 5 and 6, Example 24 to give the title compound as an orange solid (90% yield). LC/MS: RT 2.03 min, m/e 456 (M+H); 1H NMR (δ, ppm): 11.89 (1H, s), 10.6 (1H, s), 7.69 (1H, d), 7.37 (1H, s), 7.34 (1H, d), 3.71-3.76 (4H, m), 3.60-3.64 (2H, m), 3.45-3.50 (4H, m), 3.32-3.31 (4H, m), 2.92-3.00 (2H, m), 2.41 (2H, q), 2.35 (3H, s), 1.10 (3H, t).

Provenance & Evidence