1-Piperonylpiperazine → HCID 67492338, compound

Participants

Reaction Steps

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 1-benzo[1,3]dioxol-5-ylmethyl-piperazine as described in Steps 5 and 6, Example 24 to give the title compound as a yellow glass (61% yield). LC/MS: RT 2.33 min, m/e 502 (M+H); 1H NMR (δ, ppm): 11.88 (1H, s), 10.79 (1H, s), 7.66 (1H, d), 7.36 (1H, s), 7.32 (1H, d), 7.16 (1H, s), 6.98 (2H, s), 6.05 (2H, s), 4.24 (2H, s), 3.69-3.77 (2H, m), 3.37-3.40 (2H, m), 3.14-3.17 (2H, m), 2.86-2.94 (2H, m), 2.40 (2H, q), 2.33 (3H, s), 1.10 (3H, t).

Provenance & Evidence