(S)-(+)-2-(Anilinomethyl)pyrrolidine → HCID 67492439, compound

Participants

Reaction Steps

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with (S)-phenyl-pyrrolidin-2-ylmethyl-amine as described in Steps 5 and 6, Example 24 to give the title compound as a yellow glass (77% yield). LC/MS: RT 3.29 min, m/e 458 (M+H); 1H NMR (δ, ppm): 11.84 (1H, s), 7.65 (1H, d), 7.35 (1H, s), 7.25 (1H, d), 7.14 (2H, t), 6.74 (2H, d), 6.62 (1H, t), 3.76 (1H, m), 3.34-3.45 (2H, m), 3.06-3.20 (2H, m), 2.39 (2H, q), 2.30 (3H, s), 1.86 (2H, m), 1.51-1.58 (2H, m), 1.09 (3H, t).

Provenance & Evidence