Tetrahydrofurfurylamine → HCID 58808544, compound

Participants

Reaction Steps

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with (tetrahydrofuran-2-yl)methylamine as described in Step 5, Example 24 to give the title compound as a yellow solid (39.5% yield). LC/MS: RT 2.63 min; m/e 383 (M+H); 1H NMR (CDCl3, δ, ppm): 11.21 (H, br), 7.50 (1H, d), 7.23 (1H, s), 6.90 (1H, d), 4.98 (1H, t), 4.00 (1H, q), 3.80 (2H, m), 3.30 (1H, m), 3.05 (1H, m), 2.6 (2H, dd), 2.40 (3H, s), 1.87 (3H, m), 1.23 (3H, t).

Provenance & Evidence