1-Amino-2-propanol → HCID 11595582, compound

Participants

Reaction Steps

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 1-aminopropan-2-ol as described in Step 5, Example 24 to give the title compound as a yellow solid (59% yield). LC/MS: RT 2.33 min; m/e 357 (M+H); 1H NMR (CDCl3, δ, ppm): 11.13 (1H, br), 7.52 (1H, d), 7.23 (1H, s), 6.91 (1H, d), 5.27 (1H, m), 4.00 (1H, m), 3.20 (1H, m), 2.90 (1H, m), 2.53 (2H, q), 2.40 (3H, s), 2.01 (1H, s), 1.20 (6H, m).

Provenance & Evidence