Phenylethanolamine → HCID 11575321, compound

Participants

Reaction Steps

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 2-amino-1-phenylethanol as described in Step 5, Example 24 to give the title compound as a yellow solid (58% yield). LC/MS: RT 2.68 min; m/e 419 (M+H); 1H NMR (CDCl3, δ, ppm): 11.30 (1H, br), 7.58 (1H, d), 7.40 (5H, m), 6.90 (1H, d), 5.33 (1H, br), 4.90 (1H, m), 3.47 (1H, m), 3.22 (1H, m), 2.60 (2H, q), 2.44 (3H, s), 1.22 (3H, t).

Provenance & Evidence