1-(2-Pyrimidinyl)piperazine → HCID 11663028, compound

HRID 1921451Notes

Reaction equation

HRID 1921451 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[N:20]1([C:26]2[N:31]=[CH:30][CH:29]=[CH:28][N:27]=2)[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[ClH:19].[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([N:23]3[CH2:24][CH2:25][N:20]([C:26]4[N:27]=[CH:28][CH:29]=[CH:30][N:31]=4)[CH2:21][CH2:22]3)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 11663028HCID 11663028, compoundYield 18%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with 2-(piperazin-1-yl)pyrimidine as described in Step 5, Example 24 to give the title compound as a yellow solid (18% yield). LC/MS: RT 2.98 min; m/e 446 (M+H).

Sources & evidence

ORD record
ord-561d35a41b6c4f399042e045431b9ea5
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

Loading…