2-Chlorobenzylamine → 5-{5-[(2-Chlorobenzylamino)methyl]thiophen-2-yl}-3-ethyl-6-methyl-1H-pyridin-2-one hydrochloride

Participants

Reaction Steps

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-carbaldehyde is reacted with 2-chlorobenzylamine as described in Method A, Example 123 to give the title compound as a yellow solid (98% yield). LC/MS: RT 2.22 min; m/e 373 (M+H); 1H NMR (CD3OD, δ, ppm): 7.70 (2H, m), 7.0-7.58 (7H, m), 4.53 (2H, s), 4.28-4.47 (4H, d), 3.55 (1H, m), 2.62 (2H, q), 2.46 (3H, s), 4.46 (4H, d), 1.20 (3H, t).

Provenance & Evidence