O-Benzylhydroxylamine → 5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-furan-2-carbaldehyde-O-benzyl-oxime

HRID 1921475Notes

Reaction equation

[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[O:15][C:14]([CH:16]=O)=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[CH2:18]([O:25][NH2:26])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([O:25][N:26]=[CH:16][C:14]1[O:15][C:11]([C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=2[CH3:10])=[CH:12][CH:13]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

Reactant 2

HCID 102313O-Benzylhydroxylamine

HCID 588086555-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-carbaldehyde

Product 1

HCID 1363958725-(5-Ethyl-2-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-furan-2-carbaldehyde-O-benzyl-oxime

Procedure

Example 198 is substantially repeated except for utilizing 5-(5-ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl]furan-2-carbaldehyde and benzyloxyamine to afford the title compound. MS: m/e=337 (M+H).

Sources & evidence

ORD record: ord-0d2a1dfea5b440c28e150e7a2e70805e
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173682B2

Reaction notes

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