4-Hydroxypyrrolidine → HCID 58808600, compound

HRID 1921482Notes

Reaction equation

[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([OH:19])=O)=[CH:13][N:12]=2)[CH:4]=1)[CH3:2].[OH:20][CH:21]1[CH2:25][CH2:24][NH:23][CH2:22]1>>[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([N:23]3[CH2:24][CH2:25][CH:21]([OH:20])[CH2:22]3)=[O:19])=[CH:13][N:12]=2)[CH:4]=1)[CH3:2]

Participants

Reactant 2

HCID 982104-Hydroxypyrrolidine

HCID 58808553HCID 58808553, compound

Product 1

HCID 58808600HCID 58808600, compound

Procedure

Method 1, Example 205 is substantially repeated except for utilizing 5′-ethyl-2′-methyl-6′-oxo-1′,6′-dihydro-[2,3′]bipyridinyl-5-carboxylic acid and 3-hydroxy-pyrrolidine to afford the title compound. MS: m/e=328 (M+H).

Sources & evidence

ORD record: ord-3cee03efb2a94793b65b3b8448bce432
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173682B2

Reaction notes

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