HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-hydroxypyrrolidine-2-carboxylate → 1-(5'-Ethyl-2'-methyl-6'-oxo-1',6'-dihydro-[3,3']bipyridinyl-5-carbonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-hydroxypyrrolidine-2-carboxylate | HCID 549381 | — |
| Reactant | 5'-Ethyl-2'-methyl-6'-oxo-1',6'-dihydro-[3,3']bipyridinyl-5-carboxylic acid | HCID 58808702 | — |
| Product | 1-(5'-Ethyl-2'-methyl-6'-oxo-1',6'-dihydro-[3,3']bipyridinyl-5-carbonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester | HCID 58808521 | — |
Reaction Steps
Method 1, Example 205 is substantially repeated except for utilizing 5′-ethyl-2′-methyl-6′-oxo-1′,6′-dihydro-[3,3′]bipyridinyl-5-carboxylic acid and 4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester to afford the title compound. MS: m/e=386 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173682B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-5f74a22c374240ec9c53445db655413a |
| Source note | uspto-grants-2012_05 |