4-(2-Aminoethyl)benzoic acid → 4-{2-[(5'-Ethyl-2'-methyl-6'-oxo-1',6'-dihydro-[3,3']bipyridinyl-5-carbonyl)-amino]-ethyl}-benzoic acid

HRID 1921513Notes

Reaction equation

HRID 1921513 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[CH:12]=[N:13][CH:14]=[C:15]([C:17]([OH:19])=O)[CH:16]=2)[CH:4]=1)[CH3:2].[NH2:20][CH2:21][CH2:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([OH:29])=[O:28])=[CH:25][CH:24]=1>>[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[CH:12]=[N:13][CH:14]=[C:15]([C:17]([NH:20][CH2:21][CH2:22][C:23]3[CH:31]=[CH:30][C:26]([C:27]([OH:29])=[O:28])=[CH:25][CH:24]=3)=[O:19])[CH:16]=2)[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 5060664-(2-Aminoethyl)benzoic acidHCID 588087025'-Ethyl-2'-methyl-6'-oxo-1',6'-dihydro-[3,3']bipyridinyl-5-carboxylic acid

Product 1

HCID 588086294-{2-[(5'-Ethyl-2'-methyl-6'-oxo-1',6'-dihydro-[3,3']bipyridinyl-5-carbonyl)-amino]-ethyl}-benzoic acid

Procedure

Method 1, Example 205 is substantially repeated except for utilizing 5′-ethyl-2′-methyl-6′-oxo-1′,6′-dihydro-[3,3′]bipyridinyl-5-carboxylic acid and 4-(2-amino-ethyl)-benzoic acid to afford the title compound. MS: m/e=406 (M+H).

Sources & evidence

ORD record
ord-8e98cbd8ba8a4a5eae5b5c7d6d845366
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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