2-Methylaziridine → HCID 58808774, compound

HRID 1921535Notes

Reaction equation

[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[O:15][C:14]([C:16]([OH:18])=O)=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[CH3:19][CH:20]1[CH2:22][NH:21]1>>[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[O:15][C:14]([C:16]([N:21]3[CH2:22][CH:20]3[CH3:19])=[O:18])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2]

Participants

Reactant 2

HCID 63772-Methylaziridine

HCID 674924175-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-carboxylic acid

Product 1

HCID 58808774HCID 58808774, compoundYield 81%

Procedure

Method 1, Example 205 is substantially repeated except for utilizing 5-(5-ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-carboxylic acid and 2-methylaziridine to give the title compound (81% yield). LC/MS: RT 2.02 min; m/e 287 (M+H).

Sources & evidence

ORD record: ord-b8f7ca5f248b49bfa628633ea955d4b7
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173682B2

Reaction notes

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