4-(Trifluoromethyl)benzylamine → HCID 58808551, compound

HRID 1921541Notes

Reaction equation

HRID 1921541 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([C:16]([OH:18])=O)=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[F:19][C:20]([F:30])([F:29])[C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH2:26])=[CH:23][CH:22]=1>>[F:19][C:20]([F:29])([F:30])[C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH:26][C:16]([C:14]2[S:15][C:11]([C:5]3[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=3[CH3:10])=[CH:12][CH:13]=2)=[O:18])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 768044-(Trifluoromethyl)benzylamineHCID 67492337HCID 67492337, compound

Product 1

HCID 58808551HCID 58808551, compoundYield 75%

Procedure

Method 1, Example 205 is substantially repeated except for utilizing 5-(5-ethyl-2-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-thiophene-2-carboxylic acid and 4-trifluoromethyl-benzylamine to afford the title compound (75% yield). LC/MS: RT 3.15 min; m/e 421 (M+H).

Sources & evidence

ORD record
ord-7cc08863a43e4803834c39316bd62917
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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