2-Pyridinemethanamine → HCID 58808547, compound

HRID 1921542Notes

Reaction equation

[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([C:16]([OH:18])=O)=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[N:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH2:25][NH2:26]>>[N:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH2:25][NH:26][C:16]([C:14]1[S:15][C:11]([C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=2[CH3:10])=[CH:12][CH:13]=1)=[O:18]

Participants

Reactant 2

HCID 195092-Pyridinemethanamine

HCID 67492337HCID 67492337, compound

Product 1

HCID 58808547HCID 58808547, compoundYield 97%

Procedure

Method 1, Example 205 is substantially repeated except for utilizing 5-(5-ethyl-2-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-thiophene-2-carboxylic acid and pyridin-2-ylmethylamine to afford the title compound (97% yield). LC/MS: RT 2.07 min; m/e 354 (M+H).

Sources & evidence

ORD record: ord-7a4f5bdde45f4191b4eb8ce0b0e2cf02
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173682B2

Reaction notes

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