2-(PYRIDIN-4-YL)ACETOHYDRAZIDE → HCID 57654518, compound

HRID 1921624Notes

Reaction equation

HRID 1921624 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([NH:10][NH2:11])=O)=[CH:3][CH:2]=1.Cl[C:13]1[N:14]=[N:15][C:16]([C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)=[CH:17][CH:18]=1>>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[N:14]3[N:15]=[C:16]([C:19]4[S:20][CH:21]=[CH:22][CH:23]=4)[CH:17]=[CH:18][C:13]3=[N:11][N:10]=2)=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 4605582-(PYRIDIN-4-YL)ACETOHYDRAZIDEHCID 64047013-Chloro-6-(thiophen-2-yl)pyridazine

Product 1

HCID 57654518HCID 57654518, compound

Procedure

The title compound was prepared as described in Example 17 from 4-pyridineacetic acid hydrazide (1.81 mmol) and 3-chloro-6-thiophen-2-yl-pyridazine (0.58 mmol) as a pale yellow solid. 1H NMR (CD3OD) δ 8.50 (2H dd, J=4.6 Hz, 1.4 Hz), 8.22 (1H d, J=9.6 Hz), 7.94 (1H, dd, J=3.8 Hz, 1.2 Hz), 7.93 (1H, d, J=9.8 Hz), 7.74 (1H, dd, J=5.0 Hz, 1.0 Hz), 7.52 (2H, m), 7.23 (1H, dd, J=5.3 Hz, 3.8 Hz), 4.69 (2H, s). ESI-MS (m/z): Calcd for C15H11N5S: 293.1; found 294.2 (M+H).

Sources & evidence

ORD record
ord-8ca0b60c427846f9a89b153e482c5b64
Source dataset
uspto-grants-2012_05
Patent number
US08173654B2

Reaction notes

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