Imidazole → HCID 57654602, compound

HRID 1921630Notes

Reaction equation

HRID 1921630 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=3)=[N:9][N:10]=2)[N:7]=1.[NH:19]1[CH:23]=[CH:22][N:21]=[CH:20]1>>[N:19]1([C:2]2[CH:3]=[CH:4][C:5]3[N:6]([C:8]([CH2:11][C:12]4[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=4)=[N:9][N:10]=3)[N:7]=2)[CH:23]=[CH:22][N:21]=[CH:20]1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 16737904HCID 16737904, compound

Product 1

HCID 57654602HCID 57654602, compound

Procedure

The title compound was prepared from 4-(6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-phenol (Example 45: step a) and imidazole as described in Example 43. 1H-NMR (CD3OD): δ 9.78 (1H, t, J=1.3 Hz), 8.54 (1H, d, J=9.9 Hz), 8.38 (1H, t, J=1.8 Hz), 7.97 (1H, d, J=9.9 Hz), 7.83 (1H, dd, J=1.3, 1.8 Hz), 7.23 (2H, d, J=8.6 Hz), 6.72 (2H, d, J=8.6 Hz), 4.53 (s, 2H). ESI-MS (m/z): Calcd. for C15H12N6O: 292.1; found: 293.2 (M+H).

Sources & evidence

ORD record
ord-28ecac8972de42c2ad224d3f0a4f5557
Source dataset
uspto-grants-2012_05
Patent number
US08173654B2

Reaction notes

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