Hydrazine → HCID 57654536, compound

HRID 1921640Notes

Reaction equation

HRID 1921640 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[C:10]([Cl:15])[CH:9]=[CH:8]2.[NH2:17][NH2:18]>CO>[Cl:15][C:10]1[CH:9]=[CH:8][C:7]2[C:12](=[CH:13][CH:14]=[C:5]([CH2:4][C:3]([NH:17][NH2:18])=[O:2])[CH:6]=2)[N:11]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 57654529HCID 57654529, compound

Product 1

HCID 57654536HCID 57654536, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(2-Chloro-quinolin-6-yl)-acetic acid methyl ester (0.160 g, 0.679 mmol), hydrazine (0.218 g, 6.79 mmol) and methanol (3 mL) were stirred at room temperature. The reaction was evaporated to give (2-chloro-quinolin-6-yl)-acetic acid hydrazide. This compound was not purified and was used directly in the next step. 1H NMR (400 MHz, DMSO-d6) δ 9.39 (m, 1H), 8.43 (d, 1H, J=9.2 Hz), 7.91 (m, 2H), 7.75 (m, 1H), 7.58 (m, 1H), 4.30 (bs, 2H), 3.57 (s, 2H).

Workup

  1. customThe reaction was evaporated

Sources & evidence

ORD record
ord-02eced261dd94ba892fa607f47daf4d9
Source dataset
uspto-grants-2012_05
Patent number
US08173654B2

Reaction notes

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