化工社化工社 化学情報印刷レポート · 研究参考用
Gamma-Aminobutyric Acid → Butanoic acid, 4-(benzoylamino)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Gamma-Aminobutyric Acid | HCID 119 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Butanoic acid, 4-(benzoylamino)- | HCID 37118 | 74.7% |
反応手順
6.4 g of gamma-aminobutyric acid and 4.5 g of sodium hydroxide were dissolved in 100 mL of purified water, and 7.9 g of benzoyl chloride was dropwise added thereto under ice-cooling. After stirring the mixture for 6 hours, hydrochloric acid was added to adjust the pH to 2 or less. The precipitated crude product was filtered, and then recrystallized with ethanol solution to give 8.7 g of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08173705B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-bdf48983f8254f7ebce359772f7257cc |
| 出典メモ | uspto-grants-2012_05 |