Lithium hydroxide, monohydrate → 2-Amino-2-(6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propane-1,3-diol

Participants

Reaction Steps

A solution of compound 7 (53 mg, 0.14 mmol) and LiOH.H2O (45 mg, 1.1 mmol) in MeOH (3 ml), THF (1.5 ml) and water (3 ml) was stirred at 50° C. for 5 hours and diluted with ethyl acetate (20 ml). The solution was washed with brine (2×10 mL) and dried over magnesium sulfate and concentrated under vacuum. The residue was purified by column chromatography (Silica gel, 50% MeOH in CH2Cl2) to provide 35 mg of compound VPC104061(75%).

Provenance & Evidence