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Stannous Chloride → 4-(4-Dimethylaminomethyl-[1,2,3]triazol-1-yl)-phenylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Stannous Chloride | HCID 24479 | — |
| 反応物 | 4-{8-[4-(4-Pyridin-2-yl-[1,2,3]triazol-1-yl)-phenylamino]-imidazo[1,2-a]pyrazin-5-yl}-benzamide | HCID 17757332 | — |
| 反応物 | N,N-Dimethyl-1-(4-nitrophenyl)-1H-1,2,3-triazole-4-methanamine | HCID 58228820 | — |
| 溶媒 | Tetrahydrofuran ethanol | HCID 21873804 | — |
| 生成物 | Ammonia | HCID 222 | — |
| 生成物 | 4-(4-Dimethylaminomethyl-[1,2,3]triazol-1-yl)-phenylamine | HCID 59023094 | 59% |
反応手順
In the same way as described for Compound 154, step 2 using dimethyl-[1-(4-nitro-phenyl)-1H-[1,2,3]triazol-4-ylmethyl]-amine (0.178 g, 0.722 mmol), tin(II) chloride dehydrate (0.578 g, 2.54 mmol) in (1:1) THF/EtOH (4 mL). The residue is purified on Isolute FlashSilicaII cartridge eluting with 95:5 DCM:NH3 (7M in MeOH), to afford the desired compound as a yellow solid (93.2 mg, 59%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08173656B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-0770370d7f614523ad29a6beba17d3d4 |
| 出典メモ | uspto-grants-2012_05 |