HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 58423080, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Amino-2-morpholin-4-yl-benzamide | HCID 896321 | — |
| Reactant | 5,8-Dibromoimidazo[1,2-a]pyrazine | HCID 53485949 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 58423080 | HCID 58423080 | 67% |
Reaction Steps
In the same way as described in the general procedure for amine displacement using 5,8-dibromo-imidazo[1,2-a]pyrazine (0.131 g, 0.47 mmol), 5-amino-2-morpholin-4-yl benzamide (157 mg, 0.71 mmol), N,N-diisopropylethylamine (0.120 mL, 0.71 mmol) in iso-propanol (3.7 mL). Trituration with iPrOH and Et2O affords the title compound (127 mg, 67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173656B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-86fe2b7d66cd462ab8ca869f44f0cc21 |
| Source note | uspto-grants-2012_05 |