HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → 4-amino-2-methoxy-N-[(6-methylpyridin-3-yl)methyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 2-Methoxy-N-(6-methylpyridin-3-yl)methyl-4-nitrobenzamide | HCID 57589991 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-amino-2-methoxy-N-[(6-methylpyridin-3-yl)methyl]benzamide | HCID 57590054 | — |
Reaction Steps
A solution of 2-methoxy-N-(6-methylpyridin-3-yl)methyl-4-nitrobenzamide (448 mg, 1.49 mmol) in EtOH and EtOAc (8 mL each) is stirred and ammonium formate (375 mg, 6 mmol) and 10% Pd/C (100 mg) are added. The mixture is heated at reflux for 20 min, cooled, filtered through celite, the solid is washed with EtOH and the combined solvents are evaporated to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173656B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-76722e8d2b004ce3a5179e597379bc7a |
| Source note | uspto-grants-2012_05 |