HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → N-(5-aminopyridin-2-yl)-2-phenylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | N-(5-nitropyridin-2-yl)-2-phenylacetamide | HCID 4350143 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(5-aminopyridin-2-yl)-2-phenylacetamide | HCID 43144587 | — |
Reaction Steps
A solution of N-(5-nitropyridin-2-yl)-2-phenylacetamide (4.35 g, 16.9 mmol) in EtOH (75 mL) and EtOAc (75 mL) is stirred at rt and ammonium formate (4.27 g) and 10% Pd/C (500 mg) are added. The mixture is heated at reflux for 30 min, cooled, filtered through celite and evaporated to afford the title compound as an off-white solid which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173656B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-9867299630f643cdaf4402d3a1d86ca3 |
| Source note | uspto-grants-2012_05 |