2-Methoxy-N-(6-methylpyridin-3-ylmethyl)-4-[5-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino]benzamide → [4-(1-Isopropylpiperidin-4-yl)phenyl]-[5-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amine

HRID 1921827Notes

Reaction equation

HRID 1921827 reaction equation
CO[C:3]1[CH:19]=[C:18]([NH:20][C:21]2[C:22]3[N:23]([CH:32]=[CH:33][N:34]=3)[C:24]([C:27]3[CH:28]=[N:29][NH:30][CH:31]=3)=[CH:25][N:26]=2)[CH:17]=[CH:16][C:4]=1C(NCC1C=NC(C)=CC=1)=O.BrC1N2C=CN=C2C(NC2C=CC([CH:52]3[CH2:57][CH2:56][N:55]([CH:58]([CH3:60])[CH3:59])[CH2:54][CH2:53]3)=CC=2)=NC=1>>[CH:58]([N:55]1[CH2:56][CH2:57][CH:52]([C:4]2[CH:3]=[CH:19][C:18]([NH:20][C:21]3[C:22]4[N:23]([CH:32]=[CH:33][N:34]=4)[C:24]([C:27]4[CH:28]=[N:29][NH:30][CH:31]=4)=[CH:25][N:26]=3)=[CH:17][CH:16]=2)[CH2:53][CH2:54]1)([CH3:60])[CH3:59]

Participants

3

Reactant 2

HCID 590230222-Methoxy-N-(6-methylpyridin-3-ylmethyl)-4-[5-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino]benzamideHCID 59023125(5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-[4-(1-isopropylpiperidin-4-yl)-phenyl]amine

Product 1

HCID 59023097[4-(1-Isopropylpiperidin-4-yl)phenyl]-[5-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amine

Procedure

This step may be performed using the same methods as described for Compound 184, step 4, using (5-bromo-imidazo[1,2-a]pyrazin-8-yl)-[4-(1-isopropylpiperidin-4-yl)-phenyl]amine. LCMS: Rt 0.78 min (100%) m/z (ESI) 402 (M+H)+.

Sources & evidence

ORD record
ord-916a3e8ea237497692f392dc1ab81449
Source dataset
uspto-grants-2012_05
Patent number
US08173656B2

Reaction notes

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