2-(4-{4-[5-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino]phenyl}piperidin-1-yl)acetamide → HCID 178434535, compound

HRID 1921858Notes

Reaction equation

HRID 1921858 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[N:11]3[CH:12]=[CH:13][N:14]=[C:10]3[C:9]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([CH:22]4[CH2:27][CH2:26][N:25]([CH2:28][C:29]([NH2:31])=[O:30])[CH2:24][CH2:23]4)=[CH:18][CH:17]=3)=[N:8][CH:7]=2)[CH:3]=[N:2]1.[CH3:32]C1C(B2OC(C)(C)C(C)(C)O2)=CNN=1>>[CH3:32][C:5]1[C:4]([C:6]2[N:11]3[CH:12]=[CH:13][N:14]=[C:10]3[C:9]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([CH:22]4[CH2:27][CH2:26][N:25]([CH2:28][C:29]([NH2:31])=[O:30])[CH2:24][CH2:23]4)=[CH:18][CH:17]=3)=[N:8][CH:7]=2)=[CH:3][NH:2][N:1]=1

Participants

3

Reactant 2

HCID 590230192-(4-{4-[5-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino]phenyl}piperidin-1-yl)acetamideHCID 178434487HCID 178434487, compound

Product 1

HCID 178434535HCID 178434535, compound

Procedure

This compound may be prepared using the methods as described for Compound 224, using 3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole in Step 4. LCMS: Rt=0.75 min (100%), m/z (ESI) 431 (M+H)+.

Workup

  1. customThis compound may be prepared

Sources & evidence

ORD record
ord-ed54071267d0406f8323c89c92f25893
Source dataset
uspto-grants-2012_05
Patent number
US08173656B2

Reaction notes

Loading…