Triphenylphosphonium bromide → {5-Fluoro-2-[2-(4-trifluoromethylphenyl)ethoxy]benzyl}triphenylphosphonium bromide

Participants

Reaction Steps

1.7 g (5.41 mmol) of 5-fluoro-2-[2-(4-trifluoromethylphenyl)ethoxy]benzyl alcohol and 1.76 g (5.14 mmol) of triphenylphosphine hydrobromide are heated under reflux in 20 ml of acetonitrile for three hours. A first product fraction is crystallized at −20° C. The mother liquor is concentrated, the residue is dissolved in dichloromethane, and a second fraction is crystallized with diethyl ether. A total of 2.71 g (76% of theory) of the title compound is obtained.

Provenance & Evidence