Ammonium Chloride → 4-[3-(3,5-Difluoro-4-triisopropylsilanyloxybenzyl)-4-hydroxybutyl]benzonitrile

Participants

Reaction Conditions

Reaction Steps

4879 mg (10 mmol) of 4-(4-cyanophenyl)-2-(3,5-difluoro-4-triisopropylsilanyloxybenzyl)butanoic acid are dissolved in 244 ml of THF and cooled to −10° C. under argon. Then 20.01 ml (20.01 mmol) of a 1 M borane-THF complex solution are added dropwise, and the mixture is stirred at 0° C. until reaction is complete. The mixture is hydrolyzed with saturated ammonium chloride solution and extracted with diethyl ether, and the combined organic phases are concentrated. The resulting crude product is purified by chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 9:1→4:1→2:1→1:1). 2705 mg (57% of theory) of the title compound are obtained.

Provenance & Evidence