反应详情

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0 °C

442 mg (0.51 mmol, 86%-pure) of E-5-{4-[5-[2-(4-tert-butylbenzyloxy)phenyl]-3-(3,5-difluoro-4-triisopropylsilanyloxybenzyl)pent-4-enyl]phenyl}-1H-tetrazole are charged in 12 mol of THF, cooled to 0° C., mixed with 1.18 ml (1.18 mmol) of a 1 M solution of tetra-n-butylammonium fluoride in THF with exclusion of oxygen and stirred at room temperature for 2 hours. The mixture is then added to ammonium chloride solution and extracted with ethyl acetate. The organic phase is dried over sodium sulfate and concentrated. 297 mg (0.5 mmol, 98% of theory) of the title compound are obtained.

1. extractionextracted with ethyl acetate
2. dry with materialThe organic phase is dried over sodium sulfate
3. concentrationconcentrated