(6-(2-Amino-6-oxo-1,6-dihydropurin-9-yl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl hydrogen sulfate → ((2R,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydropurin-9-yl)-3,4-dihydroxytetrahydro-furan-2-yl)methyl hydrogen sulfate

Participants

Reaction Conditions

Reaction Steps

To a solution of crude 12 (8.11 mmol) in water (8 mL) was added Amberlite 120 acidic resin (0.300 g). The mixture was heated to 70° C. for 4 hours, and then filtered while hot through a sintered glass frit. The water was removed under reduced pressure and ambient temperature to yield 5 (0.244 g, 83% for two steps).

Provenance & Evidence