HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Oxocyclobutane-1-carbonitrile → 3-(2-(5-Bromo-2-methoxypyridin-3-yl)-2-oxoethylidene)cyclobutanecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Oxocyclobutane-1-carbonitrile | HCID 13082390 | — |
| Reactant | lithium (Z)-1-(5-bromo-2-methoxypyridin-3-yl)-2-(dimethoxyphosphoryl)ethenolate | HCID 59468662 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(2-(5-Bromo-2-methoxypyridin-3-yl)-2-oxoethylidene)cyclobutanecarbonitrile | HCID 57515863 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of lithium (Z)-1-(5-bromo-2-methoxypyridin-3-yl)-2-(dimethoxyphosphoryl)ethenolate (2.0 g, 5.8 mmol) and 3-oxocyclobutanecarbonitrile (1.1 g, 12 mmol) in p-dioxane (6 ml) was heated at 120° C. by Microwave in 1 h. The mixture was cooled, taken up in H2O, extracted with EtOAc (3×), dried over MgSO4, concentrated to provide the title compound. MS (m+1): 307.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173810B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-8b8f886e6ed44fff89888d9cb63c8828 |
| Source note | uspto-grants-2012_05 |