HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 3-(((1,1-Dimethylethyl)dimethylsilyl)oxy)cyclobutanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-(((1,1-Dimethylethyl)dimethylsilyl)oxy)cyclobutanol | HCID 57515873 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(((1,1-Dimethylethyl)dimethylsilyl)oxy)cyclobutanone | HCID 57515853 | — |
Reaction Steps
A mixture of 3-(tert-butyldimethylsilyloxy)cyclobutanol (2.59 g, 13 mmol), sodium bicarbonate (3 ml, 38 mmol), and Des-Martin periodonane (7 g, 15 mmol) in DCM (40 ml) was stirred at RT in 4 h, the solid was filtered; the filtrated was purified by ISCO (5% EtOAc/Hexanes) to give the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173810B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-2f911335eb454781a4b88d8cd4924c3f |
| Source note | uspto-grants-2012_05 |