HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(6-methoxy-4-(piperazin-1-yl)naphthalen-2-yl)-N-methylpyrimidin-2-amine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(7-methoxy-3-(2-(methylamino)pyrimidin-4-yl)naphthalen-1-yl)piperazine-1-carboxylate | HCID 53257824 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(6-methoxy-4-(piperazin-1-yl)naphthalen-2-yl)-N-methylpyrimidin-2-amine hydrochloride | HCID 67305842 | — |
Reaction Steps
Tert-butyl 4-(7-methoxy-3-(2-(methylamino)pyrimidin-4-yl)naphthalen-1-yl)piperazine-1-carboxylate was dissolved in dichloromethane (25 ml) and 4.0 M HCl in dioxane (10 ml) was added to the reaction. The reaction was allowed to stir at room temperature for 15 hours and 4-(6-methoxy-4-(piperazin-1-yl)naphthalen-2-yl)-N-methylpyrimidin-2-amine hydrochloride 112 was isolated by filtration as a yellow solid (1.27 g). LC/MS (m/z): 350 [M+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173808B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-89f3dce6dd34434a9c686a00f71fc77c |
| Source note | uspto-grants-2012_05 |