Tert-butyl 3-oxopiperidine-1-carboxylate → HCID 53258406, compound

Participants

Reaction Steps

4-(6-methoxy-4-(piperidin-3-ylamino)naphthalen-2-yl)-N-methylpyrimidin-2-amine 152 was synthesized according to General Procedure E except compound 33 was used a starting material and replacing tert-butyl 4-oxopiperidine-1-carboxylate with tert-butyl 3-oxopiperidine-1-carboxylate. 1H NMR (DMSO) 400 MHz δ 9.64 (bs, 1H), 9.42 (bs, 1H), 8.42 (d, J=6.0 Hz, 1H), 8.20 (s, 1H), 7.92 (d, J=8.8 Hz, 1H), 7.81-7.70 (m, 2H), 7.47 (bs, 1H), 7.24 (dd, JA=8.8 Hz, JB=2.0 Hz, 1H), 4.24-4.16 (m, 1H), 3.98 (s, 3H), 3.51-3.44 (m, 1H), 3.29-3.22 (m, 1H), 3.09 (bs, 3H), 3.00-2.87 (m, 2H), 2.13-2.05 (m, 1H), 2.05-1.94 (m, 1H), 1.93-1.76 (m, 2H); LCMS: 364 [M+H]. Calc. for C21H25N5O 3.1 Hydrochloric Acid 0.85 Dichloromethane 0.4 Ethyl Acetate: C, 51.45; H, 5.89; N, 12.79; Found C 51.58, H 5.71, N 12.79.

Provenance & Evidence