HCID 67305125, compound → HCID 178495266, compound

Participants

Reaction Steps

4-{4-[4-(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-6-methoxy-2-naphthyl}-N-(3-methoxypropyl)pyrimidin-2-amine was synthesized according to General Procedure E except 4-(6-methoxy-4-(piperazin-1-yl)naphthalen-2-yl)-N-(3-methoxypropyl)pyrimidin-2-amine and 3-bromo-4-chloro-1H-pyrazolo[3,4-d]pyrimidine were used. 4-{4-[4-(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-6-methoxy-2-naphthyl}-N-(3-methoxypropyl)pyrimidin-2-amine (177) was isolated as a yellow solid. M.p.=225-227° C. LCMS (m/z): 605 [M+H].

Provenance & Evidence