Guanidine → HCID 53257951, compound

Participants

Reaction Steps

4-[3-(2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}pyrimidin-4-yl)-7-methoxy-1-naphthyl]piperazine-1-carboximidamide was synthesized according to General Procedure A: guanidine formation except N-[2-(3,4-dimethoxyphenyl)ethyl]-4-(6-methoxy-4-piperazin-1-yl-2-naphthyl)pyrimidin-2-amine (0.020 g, 0.035 mmol) was used. The reaction mixture was triturated with ether (10 mL) to obtain 4-[3-(2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}pyrimidin-4-yl)-7-methoxy-1-naphthyl]piperazine-1-carboximidamide 203 as a of yellow solid (0.010 g). LC/MS (m/z): 543 [M+H].

Provenance & Evidence