Magnesium Chloride → HCID 178488147, compound

HRID 1922002Notes

Reaction equation

HRID 1922002 reaction equation
[K].[CH3:2][O:3][C:4]1[CH:25]=[CH:24][C:7]2[NH:8][C:9]([S@:11]([CH2:13][C:14]3[C:19]([CH3:20])=[C:18]([O:21][CH3:22])[C:17]([CH3:23])=[CH:16][N:15]=3)=[O:12])=[N:10][C:6]=2[CH:5]=1.[Cl-].[Mg+2].[Cl-]>O>[CH3:23][C:17]1[CH:16]=[N:15][C:14]([CH2:13][S+:11]([O-:12])[C:9]2[NH:8][C:7]3[CH:24]=[CH:25][C:4]([O:3][CH3:2])=[CH:5][C:6]=3[N:10]=2)=[C:19]([CH3:20])[C:18]=1[O:21][CH3:22]

Participants

5

Reactant 3

HCID 5360315Magnesium ChlorideHCID 5462222PotassiumHCID 9568614Esomeprazole

Product 1

HCID 178488147HCID 178488147, compoundYield 72.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

Potassium salt of (S)-5-Methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylsulfinyl]-1H-benzimidazole (Esomeprazole potassium) (6.2 gm) was dissolved in water (80 ml). To this solution, was added magnesium chloride solution (1.8 gm in 50 ml water), and then the contents were stirred for 1 hour at 25° C. The solid precipitated was filtered, washed with water and dried under vacuum for 12 hours at 40° C. to obtain 4.5 gm of esomeprazole magnessium dihydrate (enantiomeric excess: 99.5%).

Workup

  1. customThe solid precipitated
  2. filtrationwas filtered
  3. washwashed with water
  4. customdried under vacuum for 12 hours at 40° C.

Sources & evidence

ORD record
ord-b71c0cd7ba9e4709a445a9859347f6a9
Source dataset
uspto-grants-2012_05
Patent number
US08173817B2

Reaction notes

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