Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Pyridine, 5-ethyl-2-vinyl- | HCID 222462 | — |
| Product | HCID 45095769 | HCID 45095769 | 85% |
Reaction Steps
To a stirred mixture of 225 mL 1,4-dioxane and 225 mL water, 75 g (0.5639 mol) of 5-ethyl-2-vinyl-pyridine was added, followed by 149 g (0.8371 mol) N-bromosuccinimide was added in to it. Reaction mixture was stirred at 25-30° C. for 4 hr. and subsequently quenched with excess water. Product was extracted with dichloromethane. Organic layer was separated and dried over calcium chloride. On concentrating the organic layer and purifying the residue, it gave 110.24 g (85%) of desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08173816B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-48aeef9c185f4affb221a0718b515e00 |
|---|
| Source note | uspto-grants-2012_05 |
|---|
