HuagongsheHuagongshe Chemistry Print Report · For research reference only
[2-Ethyl-8-fluoro-3-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinolin-5-yloxy]acetic acid methyl ester → [4-Difluoromethoxy-2-ethyl-8-fluoro-3-(4-methoxybenzyl)quinolin-5-yloxy]acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [2-Ethyl-8-fluoro-3-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinolin-5-yloxy]acetic acid methyl ester | HCID 67458777 | — |
| Reactant | Chlorodifluoromethyl acetate | HCID 86613376 | — |
| Product | [4-Difluoromethoxy-2-ethyl-8-fluoro-3-(4-methoxybenzyl)quinolin-5-yloxy]acetic acid methyl ester | HCID 67457390 | — |
Reaction Steps
The title compound was prepared by the method of Preparation 1d using [2-ethyl-8-fluoro-3-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinolin-5-yloxy]acetic acid methyl ester and acetic acid chlorodifluoromethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173812B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-ce815564420c4264b86895f7948bd9fa |
| Source note | uspto-grants-2012_05 |