HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-2-(tributylstannyl)-1H-imidazole → HCID 67492166, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-2-(tributylstannyl)-1H-imidazole | HCID 2763252 | — |
| Reactant | HCID 66717642 | HCID 66717642 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 67492166 | HCID 67492166 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of [3-(4-bromobenzyl)-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy]acetic acid methyl ester (0.22 g), 1-methyl-2-tributylstannanyl-1H-imidazole (0.50 g), tetrakis(triphenylphosphine)palladium(0) (0.055 g) and 1,4-dioxane (4.4 mL) was heated at 100° C. for 1 hour. The mixture was cooled to room temperature and used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173812B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-b7a0183e1f204fd9a78fd322b8a7be61 |
| Source note | uspto-grants-2012_05 |