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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1922102Generated: November 2, 2026

Chlorodifluoromethane → [8-Chloro-2-difluoromethoxy-4-methyl-3-(4-pyrazol-1-ylbenzyl) quinolin-5-yloxy]acetic acid methyl ester

https://huagongshe.com/reaction/1922102

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChlorodifluoromethaneHCID 6372—
Reactant[8-Chloro-4-methyl-2-oxo-3-(4-pyrazol-1-ylbenzyl)-1,2-dihydroquinolin-5-yloxy]acetic acid methyl esterHCID 67459078—
Product[8-Chloro-2-difluoromethoxy-4-methyl-3-(4-pyrazol-1-ylbenzyl) quinolin-5-yloxy]acetic acid methyl esterHCID 67457920—

Reaction Steps

The title compound was prepared by the method of Preparation 10c using [8-chloro-4-methyl-2-oxo-3-(4-pyrazol-1-ylbenzyl)-1,2-dihydroquinolin-5-yloxy]acetic acid methyl ester and chlorodifluoromethane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08173812B2
Source datasetuspto-grants-2012_05
ORD IDord-665f378c4f684224ad998b5307f2a7cb
Source noteuspto-grants-2012_05