Ethyl isobutyrylacetate → 4-Methyl-3-oxo-2-(4-pyrazol-1-ylbenzyl)pentanoic acid ethyl ester

HRID 1922117Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:11])[CH2:5][C:6](=[O:10])[CH:7]([CH3:9])[CH3:8])[CH3:2].Br[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH:24]=[CH:23][CH:22]=[N:21]2)=[CH:16][CH:15]=1>>[CH2:1]([O:3][C:4](=[O:11])[CH:5]([CH2:13][C:14]1[CH:15]=[CH:16][C:17]([N:20]2[CH:24]=[CH:23][CH:22]=[N:21]2)=[CH:18][CH:19]=1)[C:6](=[O:10])[CH:7]([CH3:8])[CH3:9])[CH3:2]

Participants

Reactant 2

HCID 81583Ethyl isobutyrylacetate

HCID 27764791-[4-(Bromomethyl)Phenyl]-1H-Pyrazole

Product 1

HCID 674576524-Methyl-3-oxo-2-(4-pyrazol-1-ylbenzyl)pentanoic acid ethyl ester

Procedure

The title compound was prepared by the method of Preparation 1b using 4-methyl-3-oxopentanoic acid ethyl ester and 1-(4-bromomethylphenyl)-1H-pyrazole.

Sources & evidence

ORD record: ord-dd88560eec5d44a6ad76a2169f11897d
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173812B2

Reaction notes

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