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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1922137Generated: November 1, 2026

Chlorodifluoromethane → [3-(4-Bromobenzyl)-8-chloro-2-difluoromethoxy-4-methylquinolin-5-yloxy]acetic acid tert-butyl ester

https://huagongshe.com/reaction/1922137

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChlorodifluoromethaneHCID 6372—
ReactantHCID 67458954HCID 67458954—
Product[3-(4-Bromobenzyl)-8-chloro-2-difluoromethoxy-4-methylquinolin-5-yloxy]acetic acid tert-butyl esterHCID 67458314—

Reaction Steps

The title compound was prepared by the method of Preparation 10c using [3-(4-bromobenzyl)-8-chloro-4-methyl-2-oxo-1,2-dihydroquinolin-5-yloxy]acetic acid tert-butyl ester and chlorodifluoromethane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08173812B2
Source datasetuspto-grants-2012_05
ORD IDord-d16cb151c19e411ea03a097cab6af4f5
Source noteuspto-grants-2012_05