HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Propan-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → {8-chloro-2-difluoromethoxy-3-[4-(1-isopropyl-1H-pyrazol-4-yl)benzyl]-4-methylquinolin-5-yloxy}acetic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Propan-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 46738021 | — |
| Reactant | [3-(4-Bromobenzyl)-8-chloro-2-difluoromethoxy-4-methylquinolin-5-yloxy]acetic acid tert-butyl ester | HCID 67458314 | — |
| Product | {8-chloro-2-difluoromethoxy-3-[4-(1-isopropyl-1H-pyrazol-4-yl)benzyl]-4-methylquinolin-5-yloxy}acetic acid tert-butyl ester | HCID 67457949 | — |
Reaction Steps
The title compound was prepared by the method of Preparation 22b using [3-(4-bromobenzyl)-8-chloro-2-difluoromethoxy-4-methylquinolin-5-yloxy]acetic acid tert-butyl ester and 1-isopropyl-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-1H-pyrazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173812B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-e9909e6137f943faabad22190bc5b088 |
| Source note | uspto-grants-2012_05 |